Massive hemoptysis in cystic fibrosis.

نویسندگان

  • Patrick A Flume
  • James R Yankaskas
  • Myla Ebeling
  • Thomas Hulsey
  • Leslie L Clark
چکیده

BACKGROUND Massive hemoptysis is a complication commonly reported in patients with cystic fibrosis (CF). An understanding of the pathophysiology of this complication and its consequences is important for the management of patients with CF. OBJECTIVES To identify risk factors associated with massive hemoptysis, and to determine the prognosis of patients following an episode of massive hemoptysis. DESIGN A retrospective, observational cohort study of the National CF Patient Registry between the years 1990 to 1999. PATIENTS The Registry contained data on 28,858 patients with CF observed over 10 years at CF centers across the United States. RESULTS Massive hemoptysis occurred with an average annual incidence of 0.87% and in 4.1% of patients overall. There was no increased occurrence by sex, but it was more prevalent in older patients (mean age, 24.2 +/- 8.7 years [+/- SD]) with more severe pulmonary impairment (nearly 60% of patients who had an episode of massive hemoptysis had FEV1 < 40% predicted). The principal risks associated with an increased occurrence of massive hemoptysis included the presence of Staphylococcus aureus in sputum cultures (odds ratio [OR], 1.3) and diabetes (OR, 1.1). There was an increased morbidity (eg, increased hospitalizations and hospital days) and an increased 2-year mortality following massive hemoptysis. CONCLUSION Massive hemoptysis is a serious complication in CF patients, occurring more commonly in older patients with more advanced lung disease. Nearly 1 in 100 patients will have this complication each year. There is an attributable mortality to the complication and considerable morbidity, resulting in increased health-care utilization and a measurable decline in lung function.

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عنوان ژورنال:
  • Chest

دوره 128 2  شماره 

صفحات  -

تاریخ انتشار 2005